Clonidine vs. Epinephrine: A Safe Alternative for Intraoral Anesthesia in Diabetic Patients

A recent clinical trial has provided valuable insights into the effects of clonidine and epinephrine as vasoconstrictors in local anesthesia for patients with and without type 2 diabetes mellitus (DMT2). The study aimed to assess intraoral soft tissue anesthesia parameters, cardiovascular function, and postoperative side effects following maxillary infiltration anesthesia with 2% lidocaine combined with either clonidine (15 mcg/ml) or epinephrine (1:100,000).

The trial included 63 diabetic and 52 non-diabetic patients scheduled for tooth extractions. Patients were randomly assigned to receive 2 ml of lidocaine with clonidine (LC) or 2 ml of lidocaine with epinephrine (LE). Results indicated that anesthesia onset was significantly faster in diabetic patients regardless of the anesthetic solution used. However, the duration of anesthesia was notably prolonged in diabetic patients compared to their non-diabetic counterparts, particularly in the DMT2-LE group, which exhibited a 59% longer anesthetic duration than non-diabetics receiving LE.

Furthermore, maxillary infiltration anesthesia lasted 37.9% longer in diabetic patients receiving LE compared to those receiving LC. The width of the anesthetic field was also significantly greater in diabetics than in non-diabetics, with the DMT2-LE group showing the most extensive anesthetic spread. Cardiovascular assessments revealed a significant decrease in systolic blood pressure within the LC groups from the 15th to 30th minute post-injection. In contrast, a notable increase in heart rate was observed in both diabetic and non-diabetic patients who received LE.

Postoperative evaluations showed that paresthesia was significantly more prevalent in diabetic patients who received LE, whereas no such cases were reported in non-diabetics. These findings suggest that clonidine may serve as a safer alternative to epinephrine in intraoral anesthesia for diabetic patients, providing effective anesthesia while minimizing cardiovascular risks and postoperative side effects. This study highlights the potential for tailored anesthetic strategies to improve clinical outcomes for patients with diabetes undergoing dental procedures.

Read the entire article here: https://doi.org/10.1016/j.jebdp.2025.102097