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Does Foraminal Enlargement Increase Postoperative Pain After Root Canal Treatment?

Foraminal enlargement aims to improve cleaning at the apical end of the root canal, but could the technique increase discomfort after treatment? A new systematic review examines clinical trial evidence and raises questions about how dentists weigh apical disinfection against postoperative symptoms.

Dr. Zainab Rangwala

Dr. Zainab Rangwala

Chief Dentist · GDCHJ

3 min read2 views

Abstract

Foraminal enlargement aims to improve cleaning at the apical end of the root canal, but could the technique increase discomfort after treatment? A new systematic review examines clinical trial evidence and raises questions about how dentists weigh apical disinfection against postoperative symptoms.

During root canal treatment, how far should instrumentation extend at the apical end? Foraminal enlargement is intended to improve cleaning around the apical foramen, potentially reducing the microbial burden in an area that is difficult to disinfect.

A systematic review and meta-analysis published in Restorative Dentistry & Endodontics on 1 October 2026 examined this question in adults undergoing single-visit root canal treatment for asymptomatic necrotic permanent teeth. The findings suggest that foraminal enlargement is associated with greater postoperative pain, although the available evidence is not strong enough to support a blanket recommendation against the technique.

Six clinical trials, 426 teeth

The review by Mohammad Sabeti and colleagues followed PRISMA 2020 guidance and was registered in PROSPERO. The researchers searched MEDLINE, Web of Science, Embase and Cochrane Central for randomised controlled trials published up to 20 May 2025.

Six trials involving 426 teeth met the inclusion criteria. The studies compared single-visit nonsurgical root canal treatment performed with foraminal enlargement against treatment without it. The researchers assessed risk of bias using the revised Cochrane RoB 2 tool and pooled the results using a random-effects model.

Across the included trials, the overall analysis found significantly greater postoperative pain in the foraminal-enlargement group. The pooled standardised mean difference was 1.02, with a 95% confidence interval of 0.24–1.80 and a p-value of 0.01.

Subgroup analyses also identified statistically significant differences at 12 and 72 hours after treatment. However, the results varied considerably between studies. Statistical heterogeneity was substantial, with an I² value of 92.3%. The certainty of the evidence was graded as low, largely because of this inconsistency.

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Written by

Dr. Zainab Rangwala

Dr. Zainab Rangwala

Chief Dentist · GDCHJ

With over 12 years of clinical experience, Dr. Zainab Rangwala brings a unique blend of clinical expertise and communication excellence to her role as the Media and PR Head at DentalReach. Passionate about bridging the gap between dentistry and digital communication, she plays a key role in shaping the platform’s voice and outreach.

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