During root canal treatment, how far should instrumentation extend at the apical end? Foraminal enlargement is intended to improve cleaning around the apical foramen, potentially reducing the microbial burden in an area that is difficult to disinfect.
A systematic review and meta-analysis published in Restorative Dentistry & Endodontics on 1 October 2026 examined this question in adults undergoing single-visit root canal treatment for asymptomatic necrotic permanent teeth. The findings suggest that foraminal enlargement is associated with greater postoperative pain, although the available evidence is not strong enough to support a blanket recommendation against the technique.
Six clinical trials, 426 teeth
The review by Mohammad Sabeti and colleagues followed PRISMA 2020 guidance and was registered in PROSPERO. The researchers searched MEDLINE, Web of Science, Embase and Cochrane Central for randomised controlled trials published up to 20 May 2025.
Six trials involving 426 teeth met the inclusion criteria. The studies compared single-visit nonsurgical root canal treatment performed with foraminal enlargement against treatment without it. The researchers assessed risk of bias using the revised Cochrane RoB 2 tool and pooled the results using a random-effects model.
Across the included trials, the overall analysis found significantly greater postoperative pain in the foraminal-enlargement group. The pooled standardised mean difference was 1.02, with a 95% confidence interval of 0.24–1.80 and a p-value of 0.01.
Subgroup analyses also identified statistically significant differences at 12 and 72 hours after treatment. However, the results varied considerably between studies. Statistical heterogeneity was substantial, with an I² value of 92.3%. The certainty of the evidence was graded as low, largely because of this inconsistency.
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