HISTORY
- Coronaviridae, a monophyletic cluster in nidovirales, RNA positive stranded enveloped virus.
- Three classes of CoV
- Vertebrate : mammals ( Corona & Toro virus),
- Birds (Corona virus),
- Fish ( Bafiniviruses).
- Measuring approximately from 120-160nm to 400-500microns.
- Corona viruses are the largest RNA viruses identified so far.
- Corona virus a threat to domestic animals & pets.
- Dog = canine corona virus type I & II
- Cat = feline corona virus type I & II
- Cow = bovine corona virus
- Horse = equine corona virus
- Human corona virus exits with types 229E, NL63, OC43 and SARS related corona virus.
- Regarding infectivity: In humans only E protein is identified as a virulent factor of corona family associated with SARS-CoV.
- In humans corona virus targets primarily the epithelial cells of gastro intestinal and respiratory tract. Any pre existing infection in and around these tracts favours corona seeding.
- Studies have shown that Rodent CoV can cause hepatitis with severe neurological infections resulting in paralysis & demyelisation leading to neuropathogesis of humans in multiple sclerosis.
- Human corona viruses like beta corona virus ( HCoV-OC43) & alpha corona virus (HCoV-229E) isolated from common cold cases in humans
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