Anorganic Porcine Bone Mineral-Cancellous (0.25-1.0mm)

• Karl Schumacher Xenograft particulate is an osteoconductive, porous, anorganic bone mineral with carbonate apatite structure derived from porcine cancellous bone

• Available in jar or syringe

• Highly porous€šÄö - more space available for new bone deposition

• Rough surface facilitates cell adhesion and spread for bone in-growth 1

• Carbonate apatite structures are better osteoconductive materials than hydroxyapatite 2,3,4

• Resorption and remodeling profiles of carbonate apatite are more similar to native or normal human bone than those of synthetic materials, such as hydroxyapatite or tricalcium phosphate 4

1. Deligianni DD, Katsala ND, Koutsoukos PG, Missirlis YF, Effect of Surface Roughness of Hydroxyapatite on Human Bone Marrow Cell Adhesion, Proliferation, Differentiation and Detachment Strength. Elsevier Biomaterials 22 (2001) 87-96. 2. Spense G., Patel N., Brooks R., Rushton N. 2009. Carbonate Substituted Hydroxyapatite: Resorption by Osteoclasts Modifi es the Osteoblastic Response. Journal of Biomedical Materials Research Part A. 3. Ellies LG, Carter JM, Natiella JR, Featherstone JDB, Nelson DGA. 1988. Quantitative Analysis of Early In Vivo Tissue Response to Synthetic Apatite Implants. J Biomed Mater Res 22:137-148. 4. Landi E., Celotti G., Logroscino G., Tampieri A. 2003. Carbonated Hydroxyapatite as Bone Substitute. Journal of the European Ceramic Society 23: 2931-2937.