Abstract
This research was done on patients who were suffering from tolerable painful lesions in the oral cavity. These lesions were oral ulcers with soft consistency and the size of the oral ulcers varied from 2 mm to 8 mm respectively. They were treated using L-ornithine-L-aspartate & Silymarin suspension/ syrup and tablet Ursdeoxycholic acid 300 mg.Introduction - All about oral ulcers
Oral ulcers are painful lesions in the oral cavity. They vary in size and their symptoms depend on the type of ulcer. Etiology: The exact cause is still not known and the etiology varies from person to person. However, there are some common causes and aggravating factors such as:- Biting the tongue or inside of cheek( buccal mucosa).
- Braces, poor fitting dentures and other appliances that may rub against the mouth and gums (gingiva).
- A deficient restoration/ filling.
- Stress or anxiety.
- Hormonal changes during pregnancy, puberty & menopause.
- Medications including beta blockers and painkillers.
- Genetic factors.
- Conditions such as Celiac or Crohn's Disease, Vitamin B 12 or Iron deficiency, or a weakened immune system that may trigger oral ulcers to form.
- Minor Ulcers: This type can range in size of about 2mm upto about 8 mm. These ulcers typically take upto 2 weeks to get better and will cause some pain.
- Major Ulcers: Bigger than minor ulcers, major oral ulcers are often irregular in shape, maybe raised and penetrated deeper into the tissue than minor oral ulcers.They can take several weeks to go away and are likely to leave scar tissue when they clear.
- Herpetiform Ulceration (HU): Herpetiform oral ulcers get their name because they resemble sores associated with Herpes. Unlike Herpes, Herpetiform Ulceration (HU) is not contagious. HU recur very quickly and it may appear that the condition never gets better.
- One or more painful sore that may appear in buccal mucosa, the roof of the mouth, the labial mucosa, or the tongue.
- The appearance of round lesions that have red edges are yellow, white or gray in middle.
- HU lesions may appear as extremely painful oral ulcers in the mouth.
- Recur very quickly .
- May increase in size , eventually coming together to form a large ragged ulcer.
- Appear anywhere in mouth.
Case report
This clinical research was done on 7 male patients, aged between 25 to 35 years of age. These patients visited the author’s private dental practice, with the complaint of painful, but tolerable oral lesions. They did not have any medical comorbodities or any history of tobacco chewing, smoking or intake of tobacco in any other forms.Their dental history was non significant -they did not have any carious tooth, broken restorations or use of any dental prosthesis. On clinical examination, these lesions were found to be present on buccal mucosa & gingiva. The consistency was soft and the size ranged from 2mm to 8 mm. It was diagnosed that the patients were suffering from minor oral ulcers. Informed consent was taken from the 7 patients who became the part of this research.All these 7 male patients were prescribed:- L-ornithine-L-aspartate, Silymarin suspension/ syrup - one and half tablespoon once a day, daily after food, for 10 days and
- Tablet Ursdeoxycholic acid 300 mg once a day ,daily after food ,for 10 days
Before
After
Before
After
Discussion
A total of 7 patients were taken into account for this research.Their oral ulcers were healed after taking the prescribed drugs; namely L-ornithine-L-aspartate, Silymarin And Ursdeoxycholic acid.- L-ORNITHINE-L-ASPARTATE: L-ornithine-L-aspartate infusion injections are used to treat skin problems like skin ulcers. It is a chemical that is broken down by the body to increase the levels of two amino acids, namely ornithine & aspartic acid. Ornithine and aspartic acid helps to reduce levels of the toxic chemical 'ammonia ' in the blood.
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