"Oral Microbes: a Potential Cause of Cerebral Abscesses?" cover
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PLYMOUTH, UK: A recent study suggests that the oral cavity should be considered a source of occult infection in cases of brain abscesses where no clear cause has been identified. Researchers investigated the presence of oral bacteria in cases of brain abscesses where no other reason was detected. Oral bacteria were found to be in large numbers in such samples and the researchers concluded that poor oral hygiene might prove to be crucial in developing brain abscesses.

Oral pathogens may prove to be a more common cause of brain abscesses than previously suspected when modern sequencing technologies, such as next-generation sequencing and metagenomics, have become available for more complex analysis of communities of bacteria within abscess tissue.

For example, a recent study has similarly reported that ‘oral/dental’ pathogens, such as Fusobacterium and S. anginosus were prominent amongst mixed bacterial populations in brain abscesses.

In this study, the records of 87 patients with brain abscesses who were hospitalized at a single UK neurosurgical center over a 16-year period were studied by the researchers. Out of this, 35 patients (40% of the cohort) had a primary source of their abscess identified or strongly suspected on clinical grounds and were allocated to the ISI (infective source identified) group and 52 (60%) patients were allocated as NSI (no infective source identified) group.

Within the ISI group, there were 14 females and 21 males (60% male) and within the NSI group, there were 20 females and 32 males (62% male). The male: female ratio was consistent between groups. There was no significant difference in the age of patients within the two groups (mean age 58.7 years for the ISI group, and 52.6 years for the NSI group).

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Representation of the frequency of identification of different bacterial species in brain abscesses from patients with an identified source of infection (ISI) group (n = 35), versus those with a non-identified source of infection (NSI) group (n = 52).

As per the findings, the occurrence of oral bacteria was thus significantly higher in patients in the NSI compared to the ISI group. Amongst all identified species, S. anginosus was of particular interest as it contributed to a high proportion of the difference between the ISI and the NSI group.

Levels of oral/dental pathogens in brain abscesses from patients with an identified source of infection (ISI) group (n = 35) versus those with a non-identified source of infection (NSI) group (n = 52). These demonstrate a significantly higher incidence of oral/dental pathogens in the NSI group compared with the ISI group, after dental infections were removed from the ISI group in this analysis) (p<0.05). Legend: Yes- oral pathogen, No- not an oral pathogen.

Lead author Dr. Holly Roy, a clinical lecturer in neurosurgery at the University of Plymouth, commented in a press release: “While many potential causes of brain abscesses are recognized, the origin of infection often remains clinically unidentified. However, it was still surprising to frequently find orally occurring bacteria in brain abscesses of unexplained origin. It highlights the importance of using more sensitive techniques to assess the oral cavity as a potential bacterial source in brain abscess patients. It also highlights the importance of improving dental care and oral hygiene more generally.”

Conclusion:

In brain abscesses when no clear infective source could be established, this research shows that bacteria typically found in the oral cavity and linked to oral and dental disease are also present. These bacteria also make up a significant majority of the bacterial subgroups in these abscesses.

It is necessary to conduct more research to ascertain the physiologic/immunologic conditions under which oral infections can penetrate the CNS. Future research on brain abscesses should also include a thorough dental screening and microbiota analysis in order to comprehend the underlying mechanisms and create preventative strategies.

Source: Oral microbes and the formation of cerebral abscesses: A single-center retrospective study

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Dr Zainab Kasid
Dr.Zainab Rangwala completed her graduation from the Goverment Dental College,Jamnagar.. Practicing since 6 years, she has a keen interest in new advances in the field of health.She is currently the head of Media and PR in Dentalreach.

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